Police expect State Highway 1 at Waitahanui, south of Taupo to be reopened within the hour following a serious crash around 5:30pm.
One person has now be flown to Waikato Hospital in a critical condition.
Up to five other people suffered lesser injuries.
Currently one lane is open but Police expect the road to be fully open by around 10pm.
Motorists are asked to remain patient and take care when passing the scene.
ENDS
Issued by Police Media Centre